Endurance Edge

Proprietary Blend (we will offer in both liquid and capsule form):

Ribose
Glucuronolactone
Malic Acid
Magnesium malate
Vitamin C
Citric acid
L-Citrulline
L-Taurine

The endurance athlete pre-workout formula provides a source of ATP fuel the body needs to move forwards with ribose, a simplified cyclic sugar used by the body as a fuels source and template in RNA synthesis.

Ribose (see below for detailed information on ribose) gets accessed by type II muscle tissue which runs deep in the musculoskeletal system.

These muscle cells do not utilize creatine, however do respond to ribose as a fuel source.

Arginine once again acts to increase blood flow to the body by relaxing the endothelial cells of the circulatory system which provides a lower blood pressure with increased blood flow that moves energy in and waste products out more efficiently.

The remaining materials in the enduro formula provides for the conversion of waste products generated by the athletic activity to a form that is removable by the body.

This becomes very important as fatigue arises from the waste by-products associated with energy production and consumption.

Furthermore, ribose and taurine have been shown in the scientific literature to strengthen the heart muscle and regulate it’s performance, which is crucial if one is to continue to push the limits of physical activity in athletic performance

Ribose, is a naturally occurring sugar used by every cell of the body. It's an essential compound in energy metabolism, serving as a building block for adenosine triphosphate (ATP)-the body's basic energy source. D-ribose is also the carbohydrate backbone of genetic material, DNA and RNA, certain vitamins and other important cellular compounds.

Research has shown that ribose helps the body to maintain healthy energy levels in the heart and muscle tissues. It maximizes energy recovery and may also increase energy reserves. If you work out more than three or four times per week, your body may not have the rest time it needs between sessions for heart and muscle energy pools to return to normal levels. Other products containing Ribose are NHS Energizer, see link: http://www.nutritionmanufacturer.com/nhs_energizer.html

 

Explanation of Key Ingredients:

Citrulline is an amino acid that supports the body in optimizing blood flow through its conversion to L-arginine and then nitric oxide. Nitric oxide is involved in vasodilatation, and low levels are associated with mental and physical fatigue and sexual dysfunction.

Citrulline, which is considered a non-essential amino acid synthesized in the intestinal tract from Glutamine, converts to Arginine in the endothelial cells. This biochemical process involves L-Aspartate and the enzymes Argininosuccinate Synthetase and Argininosuccinate Lyase, in the presence of ATP. Arginine is important for Nitric Oxide production for cardiovascular health; however, most Arginine is utilized in the liver and kidneys, and only a fraction is available for this purpose. Since Citrulline is a precursor to Arginine, it allows for increased and sustained Nitric Oxide production in the endothelium for support of circulatory function.

Oral Citrulline supplementation provides a readily available source of Citrulline for this purpose, and some recent research further indicates that Citrulline may be the preferred source of cellular Arginine. In addition Citrulline also increases energy, stimulates the immune system, and is essential for Urea Cycle function as well.

Glucuronolactone -is a fascinating compound and appears not only to be safe, but hepatoprotective. A pathway of interest is the clearance of toxic metabolites and liberation of lipophillic steroids. DGL may increase the bioavailability of an exogenous hormone being administered, thereby increasing the direct effect elicited.

Moreover, the compound could remove metabolites that could potentially be hepatotoxic and may reverse prior liver damage. DGL may also be an ergogenic aid by protecting glycogen stores and their synthesis. Lastly, it may be joint and tendon protective benefiting the athlete by potentially reducing risk of injury and associated pain.

This fully referenced article should serve as an exhaustive resource for the athlete, through scientifically-based research and theory. I would appreciate feedback from readers that have supplemented with the compound (especially in its pure form) on its performance, liver, and joint benefits

Malic acid -is both derived from food sources and synthesized in the body through the citric acid (Krebs) cycle. Its importance to the production of energy in the body during both aerobic and anaerobic conditions is well established. Under aerobic conditions, the oxidation of malate to oxaloacetate provides reducing equivalents to the mitochondria through the malate-aspartate redox shuttle. During anaerobic conditions, where a buildup of excess of reducing equivalents inhibits glycolysis, malic acids simultaneous reduction to succinate and oxidation to oxaloacetate is capable of removing the accumulating reducing equivalents. This allows malic acid to reverse hypoxias inhibition of glycolysis and energy production. This may allow malic acid to improve energy production in FM, reversing the negative effect of the relative hypoxia (a shortage of oxygen in the body).